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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling Active
Atrium Health
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting

People with Expertise

Paul Rulis

University of Missouri-Kansas City

Programs

Campus Champions

Roles

researcher/educator, research computing facilitator

Paul Rulis

Expertise

Mike Carnegie

Programs

CCMNet

Roles

CCMNet

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Expertise

Andrew Monaghan

University of Colorado, Boulder

Programs

RMACC, Campus Champions

Roles

mentor, research computing facilitator

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Expertise

People with Interest

Brian Haymore

University of Utah

Programs

Campus Champions, RMACC

Roles

mentor, research computing facilitator, ci systems engineer

Brian Haymore

Interests

+66 more tags

Dung Vu

California State University-San Bernardino

Programs

ACCESS CSSN, Campus Champions

Roles

research computing facilitator, CIP

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Interests

Xilin Qiao

Programs

ACCESS CSSN

Roles

student-facilitator

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Interests

+27 more tags