Affinity Groups

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Account and Access Management CI Facilitators A group for CI and RCD professionals responsible for developing and maintaining the Account and Access Management solutions used at their institutions. Participants are invited to share and discuss… allocation-managementadministering-hpc Login to join
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Knowledge Base Resources

Title Category Tags Skill Level
Containerized Jupyter Notebooks for HPCs Learning cloudcloud-computingopenstack +20 more tags Intermediate
High performance computing 101 Website administering-hpc Beginner
Hour of Ci Learning arcgisgisadministering-hpc Beginner

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

William Lai

Cornell University

Programs

ACCESS CSSN

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, Consultant

William KM Lai

Expertise

Charles Forsyth

University of California, Riverside

Programs

Campus Champions

Roles

regional facilitator, research computing facilitator

Charles Forsyth headshot

Expertise

Lenore Martin

University of Rhoide Island

Programs

CAREERS

Roles

researcher/educator

Lenore in office

Expertise

People with Interest

Al Tucker

Columbia University in the City of New York

Programs

Campus Champions

Roles

research computing facilitator

Placeholder headshot

Interests

David Warden

SUNY Geneseo

Programs

Campus Champions, CCMNet, ACCESS CSSN

Roles

research computing facilitator, cssn, CCMNet

black and white analog photo print portrait of David Warden in a darkroom processing tray

Interests

Swabir Silayi

George Mason University

Programs

ACCESS CSSN, CCMNet, Campus Champions

Roles

mentor, research computing facilitator, cssn, Consultant, CCMNet

Interests