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Title Category Tags Skill Level
Advanced Compilers: The Self-Guided Online Course Learning optimizationparallelizationtraining +1 more tags Advanced
Advanced Mathematical Optimization Techniques Learning optimizationpython Beginner, Intermediate, Advanced
Fine-tuning LLMs with PEFT and LoRA Video fasteroptimizationperformance-tuning +1 more tags Intermediate, Advanced

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Aaron Jezghani

Georgia Institute of Technology

Programs

Campus Champions

Roles

research computing facilitator

Expertise

Katia Bulekova

Boston University

Programs

ACCESS CSSN, Campus Champions, CAREERS, CCMNet, Northeast

Roles

mentor, research computing facilitator, CCMNet

image of Katia Bulekova

Expertise

Darshan Sarojini

Virginia Polytechnic Institute and State University

Programs

ACCESS CSSN

Roles

mentor, researcher/educator

Portrait

Expertise

People with Interest

Luis Cueva Parra

High Point University

Programs

Campus Champions

Roles

researcher/educator, research computing facilitator

Interests

Raghunandan Pratoori

Iowa State University

Programs

ACCESS CSSN

Roles

student-facilitator

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Interests

Rocio Lavado

Programs

ACCESS CSSN

Roles

student-facilitator

HEADSHOT

Interests