Affinity Groups

Logo Name Description Tags Join
Structural Biology OOD Apps This group is for researchers and support staff using structural biology tools like RELION, cryoSPARC, PHENIX, IMOD, and others through Open OnDemand. Whether you're optimizing workflows,… optimizationstructural-biologyopen-ondemand Login to join

Topics from Ask.CI

Loading topics from Ask.CI...

Knowledge Base Resources

Title Category Tags Skill Level
Advanced Compilers: The Self-Guided Online Course Learning optimizationparallelizationtraining +1 more tags Advanced
Advanced Mathematical Optimization Techniques Learning optimizationpython Beginner, Intermediate, Advanced
Fine-tuning LLMs with PEFT and LoRA Video fasteroptimizationperformance-tuning +1 more tags Intermediate, Advanced

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Calloway Sutton

Indiana University

Programs

ACCESS CSSN

Roles

cssn

Placeholder headshot

Expertise

Parameshwaran Pasupathy

Rutgers, the State University of New Jersey

Programs

ACCESS CSSN, CAREERS, CCMNet

Roles

student-facilitator, CCMNet

Placeholder headshot

Expertise

Doruk Alp MUTLU

Michigan State University

Programs

ACCESS CSSN

Roles

student-facilitator

profile photo

Expertise

People with Interest

Justin Oelgoetz

Austin Peay State University

Programs

Campus Champions, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, CCMNet

Placeholder headshot

Interests

Oriana Silva

University of North Texas

Programs

ACCESS CSSN

Roles

student-facilitator

Oriana Silva

Interests

Andrew Rigg

Programs

CAREERS

Placeholder headshot

Interests

c
+28 more tags