Matt Ferguson is an experimental biophysicist. His current research emphasis is in the area of fluorescence microscopy, specifically the development of dynamic in vivo single molecule imaging at or below the diffraction limit. An underlying theme in his research has been the interface between dynamical systems and thermodynamics in both physical and biological systems and the combination of physics, computer simulation and multidimensional data analysis to interpret the results of his experiments in a straightforward way, turning information into knowledge about a physical or biological system.