Affinity Groups
There are no Affinity Groups associated with this topic. View All Affinity Groups.
Announcements
| Title | Date |
|---|---|
| CI Pathways: Leading the Way to Effective CI Use | 02/20/25 |
| Ookami Webinar | 02/14/24 |
Upcoming Events & Trainings
| Title | Date |
|---|---|
| ACES: AI/ML Techlab in Jupyter Notebooks | 9/23/25 |
Topics from Ask.CI
Loading topics from Ask.CI...
Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Attention, Transformers, and LLMs: a hands-on introduction in Pytorch | Learning | aideep-learningmachine-learning +2 more tags | Intermediate |
| DeepChem | Tool | pytorchtensorflowcomputational-chemistry | Beginner, Intermediate, Advanced |
| fast.ai | Website | aimachine-learningpytorch +1 more tags | Beginner, Intermediate, Advanced |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Michael Blackmon
Davidson College
Programs
Campus Champions, ACCESS CSSN
Roles
mentor, research computing facilitator, ci systems engineer, cssn
Expertise
Soham Pal
University of Illinois at Urbana-Champaign
Programs
ACCESS CSSN, Campus Champions, CCMNet
Roles
mentor, researcher/educator, research computing facilitator, cssn, CCMNet
Expertise
Expertise
People with Interest
Interests
Parameshwaran Pasupathy
Rutgers, the State University of New Jersey
Programs
ACCESS CSSN, CAREERS, CCMNet
Roles
student-facilitator, CCMNet
Interests