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Announcements
| Title | Date |
|---|---|
| Ookami Webinar | 02/14/24 |
Upcoming Events & Trainings
| Title | Date |
|---|---|
| HPC Monthly Workshop: Machine Learning and BIG DATA | 1/07/25 |
Topics from Ask.CI
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Attention, Transformers, and LLMs: a hands-on introduction in Pytorch | Learning | aideep-learningmachine-learning +2 more tags | Intermediate |
| DeepChem | Tool | pytorchtensorflowcomputational-chemistry | Beginner, Intermediate, Advanced |
| fast.ai | Website | aimachine-learningpytorch +1 more tags | Beginner, Intermediate, Advanced |
Engagements
Recruiting
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting
People with Expertise
Swabir Silayi
George Mason University
Programs
ACCESS CSSN, CCMNet, Campus Champions
Roles
mentor, research computing facilitator, cssn, Consultant, CCMNet
Expertise
Expertise
Jason Wells
Harvard University
Programs
ACCESS CSSN, Campus Champions
Roles
research computing facilitator, cssn
Expertise
People with Interest
Oluwatumininu Oguntola
University of North Carolina, Chapel Hill
Programs
ACCESS CSSN, CCMNet
Roles
cssn, CCMNet
Interests
Interests
Kyle Krick
San Diego State University
Programs
ACCESS CSSN, Campus Champions
Roles
research computing facilitator, CIP
