software-installation

Affinity Groups

There are no Affinity Groups associated with this topic. View All Affinity Groups.

Upcoming Events & Trainings

Title Date
R for HPC 12/09/25
R for HPC 12/09/25
R for HPC 12/09/25

Topics from Ask.CI

Loading topics from Ask.CI...

Knowledge Base Resources

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Micholas Smith

University of Tennessee, Knoxville

Programs

ACCESS CSSN

Roles

cssn, CIP

Placeholder headshot

Expertise

Fernando Garzon

University of California, San Diego

Programs

ACCESS CSSN

Roles

mentor, research software engineer

Fernando Garzon's Profile picture

Expertise

+48 more tags

Andrew Monaghan

University of Colorado, Boulder

Programs

ACCESS CSSN

Roles

mentor

Photo of Andy Monaghan

Expertise

People with Interest

Iman Rahbari

University of Southern California

Programs

Campus Champions, ACCESS CSSN, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, cssn, CCMNet

Placeholder headshot

Interests

+47 more tags

Fernando Garzon

University of California, San Diego

Programs

ACCESS CSSN

Roles

mentor, research software engineer

Fernando Garzon's Profile picture

Interests

+49 more tags

Sean Anderson

Wake Forest University

Programs

ACCESS CSSN, Campus Champions, CCMNet, OnDemand

Roles

research computing facilitator, research software engineer, ci systems engineer, cssn, Affinity Group Leader, CCMNet

Sean Anderson

Interests