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| Title | Category | Tags | Skill Level |
|---|---|---|---|
| A guide to pip in Python | Learning | pipsoftware-installation | Beginner, Intermediate |
| Installing Rocky Linux Operating System | Learning | unix-environmentsoftware-installation | Beginner |
| Navier-Stokes Cahn-Hilliard (NSCH) for MOOSE Framework | Website | ACCESSc++python +1 more tags | Intermediate |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
People with Expertise
Sean Anderson
Wake Forest University
Programs
ACCESS CSSN, Campus Champions, CCMNet, OnDemand
Roles
research computing facilitator, research software engineer, ci systems engineer, cssn, Affinity Group Leader, CCMNet
Expertise
Katherine Nelson
Yale University
Programs
Campus Champions, CAREERS, ACCESS CSSN
Roles
mentor, administrator, Masquerade, ExportPeople, research computing facilitator, steering committee, regional admin
Expertise
Timothy Middelkoop
Internet2
Programs
ACCESS CSSN, Campus Champions, CCMNet, Great Plains
Roles
mentor, regional facilitator, researcher/educator, research computing facilitator, CCMNet
Expertise
People with Interest
Interests
Od Odbadrakh
University of Tennessee, Knoxville
Programs
ACCESS CSSN
Roles
researcher/educator, research computing facilitator
Interests
Xiaoqin Huang
Rice University
Programs
ACCESS CSSN
Roles
mentor, research computing facilitator, research software engineer, cssn
