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| Title | Category | Tags | Skill Level |
|---|---|---|---|
| A guide to pip in Python | Learning | pipsoftware-installation | Beginner, Intermediate |
| Installing Rocky Linux Operating System | Learning | unix-environmentsoftware-installation | Beginner |
| Neurodesk | Website | psychologycontainerssoftware-installation +1 more tags | Beginner, Intermediate, Advanced |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Marina Kraeva
Iowa State University
Programs
Campus Champions
Roles
CampusChampionsAdmin, research computing facilitator, Affinity Group Leader
Expertise
Expertise
Mohammadreza Hadizadeh
Central State University
Programs
Campus Champions
Roles
researcher/educator, research computing facilitator
Expertise
People with Interest
Karen Tomko
Ohio Supercomputer Center
Programs
Campus Champions
Roles
research computing facilitator, research software engineer, Affinity Group Leader
Interests
Justin Oelgoetz
Austin Peay State University
Programs
Campus Champions, CCMNet
Roles
mentor, researcher/educator, research computing facilitator, CCMNet
Interests
Ron Rahaman
Georgia Institute of Technology
Programs
Campus Champions
Roles
research software engineer
